Vet-Verified: 6 Holistic Remedies for Dogs with Mast Cell Tumors
List of Contents
A mast cell tumor (MCT) diagnosis can feel overwhelming, but it’s not without hope. As the most common malignant skin tumor in dogs, MCTs are treatable, and with the right support, many dogs continue to live happy, healthy lives.
Mast cell tumors (MCTs) arise from mast cells, which help defend the body but can also trigger inflammation. These cells release substances, such as histamine, which often cause symptoms such as itching, swelling, or irritation in affected dogs.
The goal of holistic care for dogs with mast cell tumors is to support overall well-being while complementing conventional treatments. Natural therapies can help reduce side effects, improve quality of life, and may even slow tumor progression.
Before starting any holistic remedies, be sure to consult your veterinarian or a certified pet homeopath. Personalized guidance ensures safe, effective support tailored to your dog’s specific health needs and cancer care plan.
How to Spot Mast Cell Tumors in Dogs: Warning Signs to Act On

Mast cell tumors (MCTs) in dogs can appear in many forms, making them easy to overlook at first. A key red flag is a swollen, red, and inflamed lump on the skin that may change in size or appearance.
One key behavior to watch for is sudden swelling and shrinking of the tumor, sometimes within just 24 hours. This reaction, known as Darier’s Sign, occurs when the tumor releases chemicals such as histamine, triggering rapid inflammation.
Mast cell tumors in dogs often appear as firm or slightly soft lumps on the skin. Other common symptoms include itching, localized swelling, vomiting, and signs of acid indigestion, all triggered by the tumor’s release of inflammatory compounds.
The Foundation: Why Diet is Critical for MCT Management

Cancer can trigger metabolic imbalances in dogs, a condition known as cancer cachexia. This can lead to weight loss, reduced energy, and a shorter lifespan, making early nutritional support essential.
Support MCT management with a low-carb or ketogenic diet.
Mast cell tumors (MCTs), like many malignant cancers, depend on glucose to grow and survive. This energy-producing process, known as aerobic fermentation, highlights the potential benefits of low-carbohydrate dietary support.
A calorie-restricted, carbohydrate-free ketogenic diet (KMT) limits the glucose that fuels tumor growth while increasing healthy fats and ketone bodies. This non-toxic, nutritional approach may help support cancer management in dogs with mast cell tumors.
In a published case study, a malignant cutaneous mast cell tumor (MCT) in a dog completely resolved after switching to a carbohydrate-free, calorie-restricted ketogenic diet. This remarkable outcome highlights the potential of targeted nutritional therapy in cancer support.
Prioritize whole, clean foods for healing and health.
Avoid feeding your dog processed or non-whole foods, as they often contain refined sugars and synthetic additives that can fuel inflammation and tumor growth. Prioritizing fresh, natural ingredients supports overall health and complements cancer care.
Commercial kibble and canned foods are considered processed because they undergo high heat and extrusion, which can degrade nutrients and introduce unwanted additives. Whole food alternatives, such as raw or homemade meals, are minimally processed and provide cleaner, more natural nutrition to support dogs with mast cell tumors.
Dogs with cancer often need more energy and nutrients to maintain strength and immunity. Providing high-quality animal protein is essential, as tumors can break down the dog’s own muscle tissue if dietary protein is lacking.
In Traditional Chinese Veterinary Medicine (TCVM), some holistic vets recommend feeding proteins that are considered neutral or cooling to help balance the body's energy. Options like pork, rabbit, duck, and cold-water fish are commonly used to support dogs with cancer, including mast cell tumors.
Choose anti-cancer foods that also strengthen your dog’s liver, a vital organ for detoxification and overall immune support.
Beets are packed with beta-carotene, fiber, and antioxidants that help support liver health and detoxification in dogs. Including beets in your dog’s diet may aid the body’s natural defenses against inflammation and oxidative stress.
Asparagus is a natural source of glutathione, a powerful antioxidant that supports liver detoxification. This compound helps break down carcinogens, making asparagus a smart addition to an anti-cancer diet for dogs.
Blueberries and blackberries are loaded with antioxidants that support immune health and fight oxidative stress. They also contain ellagic acid, a potent compound that may help inhibit cancer-related cell changes and growth pathways.
6 Natural Supplements and Botanicals to Help Stabilize Mast Cell Tumors in Dogs

Natural supplements and botanicals can play a powerful role in stabilizing mast cell tumors (MCTs) in dogs. When used alongside conventional care, these targeted remedies may help reduce inflammation, support immune function, and slow tumor activity.
#1. Quercetin
Quercetin is a powerful natural compound that can help reduce histamine release and inflammation in dogs with mast cell tumors. Often combined with nettles and bromelain, it supports mast cell stability and may ease allergy-like symptoms while boosting immune function.
Known as “nature’s Benadryl,” quercetin is a natural antihistamine that supports dogs with mast cell tumors by reducing allergic inflammation. It helps stabilize mast cells by blocking the release of histamines and prostaglandins, which can trigger tumor-related flare-ups.
#2. Omega-3 fatty acids (EPA)
Omega-3 fatty acids, particularly EPA, have powerful anti-inflammatory properties that may help slow tumor growth in dogs with mast cell tumors. These healthy fats support immune function, reduce chronic inflammation, and can be a valuable part of a holistic cancer care plan.
They are also powerful anti-inflammatories that may benefit dogs with mast cell tumors. Studies suggest they can help slow tumor growth, reduce metastasis risk, prevent muscle loss, and potentially extend survival time.
#3. Curcumin
Turmeric, through its active compound curcumin, offers powerful anti-inflammatory and immune-supporting properties. It may help slow the growth of mast cell tumors in dogs and support overall cancer management naturally.
As a powerful anti-inflammatory, curcumin can help stabilize mast cells and reduce reactions associated with mast cell tumors in dogs. To enhance its absorption and therapeutic effect, it's best given with a healthy fat such as coconut oil.
#4. Cannabidol
Cannabidiol (CBD) and full-spectrum hemp extract (FSHE) offer natural support for pain relief, inflammation, and cellular health in dogs with mast cell tumors. These plant-based compounds may help improve comfort, reduce stress, and support the body’s natural healing processes.
CBD and FSHE support healthy mast cell function by interacting with the body’s endocannabinoid system. They may help block pain and inflammation and show potential anti-tumor effects, making them a valuable addition to holistic care for dogs with mast cell tumors.
#5. Medicinal mushrooms
Reishi, Chaga, and Turkey Tail mushrooms are well-known for supporting immune system balance and offering potential anti-tumor benefits. These medicinal mushrooms may help the body respond more effectively to mast cell tumors by promoting healthy immune and cellular function.
Medicinal mushrooms help strengthen the immune system and support apoptosis, the body’s natural process of eliminating damaged or cancerous cells, potentially leading to tumor shrinkage. Chaga, in particular, is noted for its ability to help stabilize systemic histamine responses, making it especially beneficial for dogs with mast cell tumors.
One standout product to consider is PIPTOPET by Zumalka, a natural remedy formulated to support your pet’s immune system during cancer care. Made with the medicinal mushroom Fomitopsis betulina, it helps promote healthy cellular response and may slow abnormal growth, without harsh side effects.
This gentle formula is safe for long-term use and easy to administer, making it a convenient addition to your dog’s holistic cancer care plan. PIPTOPET is especially helpful for pets with mast cell tumors, offering immune modulation and natural support for overall vitality.
#6. Traditional Chinese Herbal Medicine
Traditional Chinese Herbal Medicine (TCHM) offers a targeted, individualized approach to supporting dogs with mast cell tumors. These time-tested herbal formulas are designed to restore balance, strengthen immune function, and address tumor growth by supporting the body’s natural healing processes.
Herbs like Xue Fu Zhu Yu Tang help promote healthy blood circulation to the skin, allowing the immune system to better target and eliminate cancer cells. Astragalus root, a warming adaptogen, supports stress resilience and may help prevent metastasis in dogs with mast cell tumors.
Holistic Lifestyle Strategies for Dogs with Mast Cell Tumors: Beyond Supplements
Supporting your dog’s entire body, especially the nervous system and circulation, is essential for slowing the progression of mast cell tumors. A balanced, holistic approach helps strengthen the body’s natural defenses and creates an environment less favorable to cancer growth.
- Chronic stress is a silent disruptor that can hinder circulation and weaken the body’s ability to heal, especially in dogs with mast cell tumors. Minimizing emotional and environmental stressors, such as long periods alone or exposure to pollutants, can support better energy flow and overall well-being.
- Traditional Chinese acupuncture can help improve the quality of life in dogs with mast cell tumors by relieving cancer-related symptoms and reducing side effects from conventional treatments. However, it’s important to avoid placing needles near the tumor site to prevent unwanted stimulation.
- To avoid overstimulating the immune system, many holistic veterinarians advise against continued vaccinations for dogs with mast cell tumors. It’s also recommended to reduce exposure to pesticides and synthetic chemicals, which can place additional stress on the immune system.
Always consult your veterinarian or a certified pet homeopath before adding new supplements or treatments. Professional guidance ensures your dog’s mast cell tumor care is safe, effective, and customized to their unique health needs.
A Final Word
Supporting a dog with mast cell tumors naturally requires a comprehensive, whole-body approach. By calming inflammation, nourishing the immune system, and enhancing circulation and nervous system health, you create a stronger internal environment that helps the body resist tumor progression.
Think of a mast cell tumor like a plant. Surgery may remove the visible growth, but if the internal environment (the “soil”) remains inflamed and sugar-rich, it can grow back. Holistic care aims to change that internal environment through targeted diet, supplements, and lifestyle support to reduce the chance of recurrence.
FAQs
What are the key physical signs of a mast cell tumor (MCT) in a dog?
A common sign of a mast cell tumor is a red, inflamed swelling on the skin that may appear suddenly. One unique trait of MCTs is their tendency to swell and shrink rapidly, sometimes within 24 hours, due to the release of histamine and other chemicals, a reaction known as Darier’s Sign. These tumors can also present as solid or semi-solid lumps, making early detection and monitoring essential.
Can natural therapies cure my dog’s mast cell tumor, or must they be used with conventional treatment?
Holistic treatments generally are not considered to be curative for cancers. However, they are highly beneficial as complementary therapies used alongside conventional treatments. The goal of this integrated approach is to improve patient welfare and quality of life, minimize the side effects caused by conventional therapies like chemotherapy, and help impede tumor growth.
What is the most important dietary strategy for managing MCTs?
Diet is crucial because mast cell tumors, like most malignant cancers, require glucose for growth. The primary nutritional strategy recommended is a carbohydrate-free, calorie-restricted ketogenic diet (KMT). This approach restricts the fermentable fuel (glucose) needed by the tumor while promoting metabolic health in normal cells. In one reported case, a malignant cutaneous MCT in a dog resolved entirely after the diet was switched to a carbohydrate-free, calorie-restricted ketogenic diet alone.
Which supplements are considered "natural antihistamines" to stabilize mast cells?
The most common sign of a mast cell tumor is a red, inflamed swelling on the skin. A distinct feature of MCTs is their ability to rapidly swell and shrink, sometimes within 24 hours, due to the release of histamine and other inflammatory chemicals, a reaction known as Darier’s Sign. These tumors may also appear as solid or semi-solid lumps, making them easy to overlook in early stages.
How do medicinal mushrooms and CBD support the immune system against MCTs?
Both medicinal mushrooms and Cannabidiol (CBD) or Full-Spectrum Hemp Extract (FSHE) provide immune system support:
- Medicinal mushrooms such as Reishi, Chaga, and Turkey Tail help strengthen the immune system. They support apoptosis (programmed cell death), which can cause tumors to shrink. Chaga, in particular, has been noted for its proven ability to stabilize systemic histamine responses.
- Mast cells possess cannabinoid receptors. FSHE or CBD interacts with these receptors to support healthy mast cell function, helps block inflammation and pain, and may possess an anti-tumor effect.
What types of food or treatments should be strictly avoided in dogs with MCTs?
To maintain metabolic and immune health, it is important to avoid feeding your pet processed/non-whole food, especially commercial kibble or tinned food, which contains refined sugar and/or synthetic ingredients.
Additionally, because MCTs involve the immune system, most holistic veterinarians recommend that dogs and cats diagnosed with mast cell cancer no longer receive vaccinations to prevent immune overstimulation. Avoiding pesticides and synthetic ingredients is also recommended.

Thanks for reaching out, Kris. We sent you an email so we can tailor a treatment to your pet’s specific needs.
Hi,
My dog, Ginger just had a mast cell tumor removed and I do not want to do chemotherapy. What can I do naturally?
Hi Joseph, thanks for reaching out. We have sent you a personal email to give you a recommendation for Shelby !! Hope to hear back from you soon
Hello! My name is Joseph and I’m desperately seeking a holistic alternative to dangerous chemo/radiation treatment for my dog Shelby who has mass cell tumors. A friend of mine lost their do to the same cancer and unfortunately the chemo led to tremendous suffering prior to death. I used natural healing when I had colon cancer in 2003 and I’m still alive. I’d like to know the most effective mass cell tumor treatments you have available. I read about alfalfa but I do not know which supplements would be best. I would greatly appreciate any brands you are sure work well for my fur baby. Any recommendations of products would greatly be appreciated.
Joseph
Leave a comment